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CD4 + T-cell subsets, T-helper 17 (Th17), and regulatory T cells (Treg) play a vital role by limiting -synuclein-mediated microglial activation and reducing the activity of CD8 + cytotoxic T-cell and natural killer (NK) cells during the neuroinflammation processes in PD ( + T-cell infiltration in the substantia nigra pars compacta was observed in the brain in early pre-symptomatic PD, which correlated with -synuclein aggregate accumulation and eventual dopaminergic neuronal cell loss ( + T-cell subsets (Zheng et al., 2020b)

Fibroblasts are essential for wound healing as they are responsible for depositing extracellular matrix proteins such as collagen, fibrin, elastin and more