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Poli M, Asperti M, Ruzzenenti P, Regoni M, Arosio P (2014) Hepcidin antagonists for potential treatments of disorders with hepcidin excess

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While general limitations of simulation-based modelssuch as assumptions about long-term drug adherence, weight maintenance, and cost trajectoriesremain relevant, future cost-effectiveness studies should prioritize harmonized design, updated pharmacologic comparators, and country-specific parameters to yield more clinically actionable insights