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this is critical since these organelles are major contributors to free radical generation

It is worth noting that children possess a weaker antioxidant defense than adults [28, 130]

Figure 2 3.2.1 Inhibitory pathways of ferroptosis The ferroptosis-inhibiting mechanisms include the classical GSHGPX4 axis and several GPX4-independent pathways ( transports extracellular cystine into the cell in a 1:1 exchange with intracellular glutamate release ( 2 pathway in the mitochondria: Dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme localized to the mitochondrial inner membrane, catalyzes the fourth step of pyrimidine biosynthesisconverting dihydroorotate (DHO) to orotate (OA)while transferring electrons to mitochondrial ubiquinone, reducing it to CoQ10H 2 , which acts as a radical-trapping antioxidant ( inhibitors such as sulfasalazine with DHODH inhibitors can synergistically induce ferroptosis ( 3.2.2 Activating pathways of ferroptosis Lipid peroxidation serves as the final execution mechanism of ferroptosis

I often get brain fog after eating, yet dont want to get low blood sugar from fasting, so it is always a quandary