These have been extensively studied for safety and effectiveness
Well above and beyond your typical medical clinic
The process as claimed in claim 7, wherein the solvent is selected from hydrocarbon solvents, ether solvents, ester solvents, polar-aprotic solvents, chloro solvents, ketone solvents, nitrile solvents, water and the like or mixtures thereof, the base is selected from organic bases and the coupling agent is selected from N,N'-dicyclohexylcarbodiimide (DCC), N,N"-diisopropylcarbodiimide (DIC), l-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HC1), N,N"-carbonyldiimidazole (CDI), 1- [bis(dimethylamino) methylene] - 1H- 1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), 2-( IH-benzotriazol- 1 -yl)- 1 , 1 ,3,3-tetramethyluronium hexafluorophosphate (HBTU), IH-benzotriazolium l-[bis(dimethylamino)methylene]-5- chloro-hexafluorophosphate( 1 )-3-oxide(HCTU), (benzotriazol- 1 -yloxy)tris(dimethyl amino )phosphonium hexafluoro phosphate (BOP), benzotriazol- 1-yl-oxytripyrrolidino phosphonium hexafluorophosphate (PyBOP), l-hydroxy-7-azatriazole, 1-hydroxy benzotriazole (HOBt), 1-hydroxy- 1H-1, 2, 3-triazole-4-carboxylate, O-(benzotriazol-l-yl)- N,N,N',N'-tetramethyl uranium tetrafluoroborate, N-hydroxysuccinamide, N- hydroxysulfo succinimide, ethyl cyanohydroxyiminoacetate, 7-azabenzotriazol-l- yloxy)tripyrrolidinophosphonium hexafluorophosphate, N,N,N',N'-Tetramethyl-O-(N- succinimidyl)uronium tetrafluoroborate (TSTU) or mixtures thereof
Posibles mecanismos contribuyentes: Reduccin de la ingesta de lquidos: El efecto supresor del apetito puede llevar a una disminucin no intencional del consumo de agua y otros lquidos, resultando en deshidratacin leve y sequedad de las mucosas orales
