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Mechanistically, IGFBP-2 can activate STAT3 to increase the transcriptional activity of C-X-C motif ligand 1 (CXCL1), thereby increasing the intracellular expression level of CXCL1, which contributes to the survival of lung cancer cells in the gefitinib environment (136)

10.1001/jama.2016.10260 [DOI] [PMC free article] [PubMed] [Google Scholar] 70.Jorsal A, Kistorp C, Holmager P, Tougaard RS, Nielsen R, Hnselmann A, et al

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