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While topical application is convenient and non-invasive, the peptide faces a significant barrier: human skin is designed to keep foreign substances out

Patients should not flush tablets down the toilet or pour them into drains unless specifically instructed to do so, as this can contribute to pharmaceutical contamination of water supplies

The potential role of adjunctive bone-protective therapies - including calcium and vitamin D supplementation, weight-bearing exercise, and, in selected high-risk cases, pharmacologic agents such as bisphosphonates - should be considered on an individual basis, though no evidence specifically addresses this question in MC4R -deficient patients

Follow-up then supports titration and side-effect management