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Baseline and ongoing monitoring: Before initiating GLP-1/GIP therapy, consider measuring baseline B12 levels, particularly in patients concurrently taking metformin, those with previous bariatric surgery, individuals following plant-based diets, or those with malabsorption conditions

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

NNF19OC0055001), European Foundation for the Study of Diabetes Future Leader Award (NNF21SA0072746), and Independent Research Fund Denmark, Sapere Aude (1052-00003B)

Understanding not just what to take but how to take it most effectively translates directly into better results per dollar spent