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In published preclinical work, KPV has been studied for inhibiting NF-B activation in intestinal epithelial cells, with one widely cited study showing PepT1-mediated transport into colonic cells as part of its anti-inflammatory mechanism in mouse colitis models (Dalmasso et al., Gastroenterology , 2008)
Cellular dysregulation from continuously elevated MOTS-c might have consequences that take years to manifest
This requires daily dosing plus an insulin stimulus to drive uptake into muscle over weeks to months
Exposure to aflatoxins in animals can cause acute aflatoxicosis and death, while long-time exposure to low concentrations may cause cancer or lower performance and production of farm animals
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