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Conditions Associated with Cleft Lip and Palate One of the most common birth defects associated with cleft lip and palate is CHARGE syndrome, which is an acronym for: Coloboma (an aperture or hole in any parts of the eye, such as the iris, retina, or optic nerve) Heart defects Atresia choanae (blockage or closure of the back of the nasal passages) Growth retardation (delays or restrictions in physical growth and development) Genital abnormalities (reproductive irregularities) Ear abnormalities Children with cleft lip and palate may also have other associated conditions, such as: Treacher Collins syndrome, a genetic disorder characterized by facial deformities, specifically affecting the development of the cheekbones and jaw