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Description

This variant is very rare in gnomADv4.1.0 (0.00003036) and in a TopMED Freeze 10 database (0.000046389)

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The reduction of intracellular iron may disturb activity and homeostasis between osteoclasts and osteoblasts, leading to dysregulation of bone balance and ultimately bone loss

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Fortunately, some of this can be mitigated by eating enough protein and doing regular strength training

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Melanin is the natural pigment responsible for skin color

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