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Cross-sectional metagenomic and metabolomic cohorts consistently show a decrease in butyrate-producing taxa (e.g., Faecalibacterium, Roseburia) and an increase in mucin-degrading or pro-inflammatory genera (e.g., Akkermansia, some Enterobacteriaceae) across geographically diverse PD cohorts, with some taxa correlated with constipation, disease duration, and motor scores [57]

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This has lead to the use of alternate velocity equations which do not use the kinetic constants kcat and Km at all, instead depending on a different rate constant, (Toppo et al., 2009)