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The overall safety profile observed in the trial was consistent with the safety profiles of GLP-1 receptor agonist medications, including predominantly manageable gastrointestinal adverse events
In a single-center, 5-year prospective study of over 500 patients with type 2 diabetes, those with baseline plasma C16 levels 0.8 mol/L had a 2.8-fold higher risk of progressing to end-stage renal disease (ESRD) (HR = 2.83, 95% CI:1.624.94), independent of conventional factors such as glycemic control, blood pressure status, and UACR [145]
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