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We did not consider lipids for the viral biomass reaction since for most viruses there is only scarce information about the composition of the viral lipidome 81 and this has just recently been determined for SARS-CoV-2 82

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In our current study, inhibiting PFKFB3 with 3PO not only repressed glycolytic lactate production but also potently inhibited the activation of NLRP3 inflammasome in TGF-1 + IL-1-activated lung fibroblasts