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It is prohibited both in- and out-of-competition for all athletes subject to WADA or equivalent anti-doping jurisdiction

A 2014 pharmacokinetic study demonstrated that ketoconazole (a strong CYP3A4/P-gp inhibitor) increased apixaban AUC by approximately 100%, while rifampin (a strong inducer) decreased it by roughly 54% [1]

This skin reaction is often referred to as the tretinoin purge and is a temporary reaction as the skin adjusts

Recent studies have reported that fucoxanthin has many physiological functions and biological properties, such as antiobesity, antitumor, antidiabetes, antioxidant, anti-inflammatory, and hepatoprotective activities, as well as cardiovascular and cerebrovascular protective effects