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4.7 Pregnancy-related effects Although type 2 diabetes and obesity have been effectively treated with GLP-1 receptor agonists, their role in pregnancy and breastfeeding has been a controversial debate due to potential risks to the mothers health and fetal outcomes (87)
Mice tolerated the drug well and maintained their weights over time (Extended Data Fig
They can also help type 1 diabetes patients lose weight, something thats especially difficult for people who take insulin, which signals the body to take extra sugar out of the blood and store it as fat
This is also why retatrutide is being studied for metabolic dysfunction-associated steatotic liver disease (MASLD), where reducing liver fat is a primary clinical goal
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