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In 1955, Christian de Duve reported on acid phosphatase-positive sac-like particles in rat liver cytoplasm (Novikoff et al., 1956) and later showed acid hydrolases in these organelles, which were subsequently named lysosomes

The dual GLP-1/GIP agonist tirzepatide (Mounjaro/Zepbound) is showing superior metabolic outcomes to single-agonist GLP-1 agents in early PMOS-relevant data

When mitochondrial function is severely compromised, the integrity of the mitochondrial membrane is disrupted, leading to the release of pro-apoptotic factors into the cytoplasm