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Thus, during short-term fasting, changes in free and bioactive IGF-I rather than total IGF-I appear to be at least in part responsible for the increased GH secretion (111, 112), intermittent fasting (113), nor long-term calorie restriction (114) exerts any consistent inhibitory impact on serum IGF-I levels

Authors: Thomas Kruse, Jakob Lerche Hansen, Kirsten Dahl, Lauge Schffer, Ulrich Sensfuss, Christian Poulsen, Morten Schlein, Ann Maria Kruse Hansen, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour, Trine Ryberg Clausen, Eva Johansson, Simone Fulle, Rikke Bjerring Skyggebjerg, Kirsten Raun URL: This paper details the medicinal chemistry efforts that led to the design and synthesis of cagrilintide, a long-acting amylin analogue for the treatment of obesity

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