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Du K, Williams CD, McGill MR, Jaeschke H

The observed excellent safety profile, along with the positive results presented herein, support further evaluation of ARA 290 as a disease modifying agent in subjects with painful diabetic neuropathy

Moreover, individuals should be vigilant for signs of complications, such as sudden swelling, severe pain, or changes in bowel habits, as these may indicate a more serious underlying issue that requires urgent intervention

When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)