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List of Abbreviations Ach acetylcholine ANF atrial natriuretic factor CICR Ca 2+ -induced Ca 2+ release CNS central nervous system CBP CREB-binding protein CRE cAMP response element CREB cAMP response element-binding protein CRTC CREB-regulated transcriptional coregulator DPP-IV dipeptidyl-peptidase-IV Epac cAMP-regulated guanine nucleotide exchange factor ER extended release GLP-1R GLP-1 receptor GPCR G protein-coupled receptor GSIS glucose-stimulated insulin secretion HFD high-fat diet IRS-2 insulin receptor substrate 2 K ATP ATP-sensitive K + channel KO knockout MEN2 multiple endocrine neoplasia syndrome type 2 NDM neonatal diabetes mellitus NPY neuropeptide tyrosine PACAP pituitary adenylyl cyclase-activating peptide PG proglucagon PIP 2 phosphatidylinositol 4,5-bisphosphate PKA protein kinase A PTH parathyroid hormone PYY peptide tyrosine tyrosine RCT randomized control trial RYGB Roux-en-Y gastric bypass SNARE soluble N -ethylmaleimide-sensitive factor attachment protein receptor SUR1 sulfonylurea receptor type 1 T2DM type 2 diabetes mellitus TMAC transmembrane adenylyl cyclase TxNIP thioredoxin-interacting protein VDCC voltage-dependent Ca 2+ channel WT wild type Footnotes All authors declare no conflict of interest concerning any of the concepts addressed in this review of the literature

If blood glucose drops below 70 mg/dl, fast-acting carbs like fruit juice or glucose tablets are essential

These include your location and the pharmacy you use