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Additionally, these medications appear to enhance synaptic plasticity and may improve cerebral blood flow in preclinical models, mechanisms that could theoretically support cognitive function

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In addition, in the study of oxidative stress injury in cochlear spiral ganglion neuronal cells (SGNs), it was found that when GPX1 is knocked out, the oxidative stress damage of SGNs by peroxynitrite is aggravated, resulting in loss of SGNs and loss of hearing (Wang et al., 2022)

Its compounding-pathway status shifted in April 2026 when the FDA removed it from Category 2 of the 503A bulk substances list, though this is a compounding determination, not an approval