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Results Expression of GLP-1 and DPP-4 in human islets supported a local effect of linagliptin on islet cell function Classically deemed as a gut hormone, GLP-1 has also been shown to be produced locally within pancreatic islets as GLP-1 and glucagon share the same precursor proglucagon that is expressed by cells 24,25,26,27

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The high expression of ACMSD in the kidney and liver offers the therapeutic potential of ACMSD inhibitors, such as TES-991 and TES-1025, for renal and hepatic dysfunction