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Rare but serious adverse effects include serious allergic reactions, low blood sugar (hypoglycemia), and an increased risk of thyroid cancer, pancreatitis, gallbladder problems, and diabetic eye complications

Some of these include severe gastrointestinal issues (nausea, vomiting, diarrhea), pancreatitis, rapid weight loss, severe abdominal pain, and symptoms of thyroid cancer (such as a lump or swelling in the neck, trouble swallowing, or voice changes)

While heart palpitations are not listed as a common adverse reaction in FDA prescribing information, semaglutide can increase resting heart rate by 1-4 beats per minute, which some individuals may perceive as palpitations

Residual tirzepatide and building semaglutide are both present