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Not replicated in humans at this point, though there are people online who have stopped and started with worse results than expected after restarting, so if this turns out to be a real and substantial effect in humans , it is a very strong argument against cycling GLPs, especially if there is any underlying obesity issues, as messing up the effectiveness of the drugs that work long term does not sound like a good idea to get marginally lower body fat

Responsiveness of One-Carbon Metabolites to a High-Protein Diet in Older Men: Results from a 10-Wk Randomized Controlled Trial. Nutrition (Burbank, Los Angeles County, Calif.), vol

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