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Pharmacokinetics of SNAC and Oral Semaglutide The pharmacokinetics of oral semaglutide have been assessed in healthy individuals and people with type 2 diabetes (15,37,38)

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CONFLICTS OF INTEREST MPL and FS hold a minority interest in Lunella, Inc

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions