Hilborn, E., Stal, O., Alexeyenko, A
If caused by food (e.g., licorice, iron supplements) or medications (e.g., bismuth-based drugs), its usually harmless
Common gastrointestinal effects include: Bloating and gas : Increased fermentation activity from probiotic bacteria can produce excess intestinal gas, causing abdominal distension and discomfort Mild diarrhea or loose stools : Changes in gut flora composition may temporarily alter bowel habits Abdominal cramping : Some individuals experience mild to moderate cramping as their digestive system adapts Nausea : Less common but reported, particularly when supplements are taken on an empty stomach These symptoms are generally mild, self-limiting, and often resolve within days to weeks as the microbiome equilibrates
While this study demonstrated the potential benefits of GSH augmentation in an elderly cohort, a future study design utilizing direct or indirect GSH level measurement in larger and more heterogeneous populations could be undertaken to more precisely identify which patients may benefit from such therapy while sparing others who may have sufficient levels of GSH from unnecessary intervention
