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Decorin upregulation represents a fourth mechanism: decorin is a proteoglycan that organizes collagen fibril assembly and suppresses TGF-beta-mediated fibrosis, so its upregulation by GHK-Cu may support organized tissue repair with reduced scar formation

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The chemical mechanism by which glutathione -S- transferase is inactivated by the glutathione acrylate analog is likely based on the presence in the tertiary structure of the enzyme of a docking site where glutathione is bound and its free thiol group is deprotonated by a facing amino acid which acts as a strong proton acceptor [129]