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Others will continue for the entire time a patient takes Wegovy, and some will become lifelong health conditions for patients to manage

This methodology was developed after surveying 500+ people about their GLP-1 provider selection challenges and analyzing the actual pain points that lead to poor outcomes and wasted money

The mechanism of action centres on mimicking the naturally occurring hormone GLP-1, which is released from the intestine after eating

This offers several potential benefits: Avoids first-pass metabolism : Unlike swallowed medications that must pass through the liver, sublingual absorption delivers drugs directly to the bloodstream Bypasses stomach acid : GLP-1 peptides are degraded by digestive enzymes, so avoiding the stomach could improve stability Rich vascular network : The area under the tongue has extensive blood vessels that allow rapid absorption However, research on peptide delivery through oral mucosa reveals significant challenges: Peptides like semaglutide and tirzepatide have molecular weights around 4000 Da (compounds above 500 Da generally show poor permeability) Salivary and mucosal proteases degrade peptides before they can cross the epithelial barrier Continuous saliva production dilutes and washes away the medication Studies with insulin showed only 1-2% bioavailability via buccal/sublingual routes without absorption enhancers The key question: Do compounded ODT formulations overcome these barriers