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Ann N Y Acad Sci 2000

For individuals with thyroid disorders, such as Hashimotos thyroiditis, the potential for drug-induced changes in thyroid function necessitates careful consideration and monitoring

Ben Lynch: Recycles other antioxidants like CoQ10, but getting into cells is challenging research is ongoing to get CoQ10 intracellularly -Could doing a large dose of glutathione have a paradoxical inflammatory or pro-oxidation effect?10:42 Yes and no When glutathione donates a molecule, it becomes glutathione disulfide (GSSG) the oxidized form of glutathione You can measure GSSG in your bloodstream The pro-oxidation effect is very short-lived it will become a much more stable molecule in your body Given the right nutrients and energy, this molecule can regenerate itself and make glutathione again Individuals who have certain variants of the GSTM1 and GSTM2 genes may experience difficulties in conjugating glutathione and eliminating it from the body GSTM 1 associated with higher risk for environmentally related cancer GSTM 2 associated with Barrett's adenocarcinoma and frontonasal dysplasia DNA Testing StrateGene (use code BEN10 to save 10% off first order) Glutathione only stays in the body for about 1415 minutes -How do you develop a stable glutathione molecule?16:35 Glutathione is a highly unstable molecule consisting of three parts Glutamine an amino acid that plays a key role in protein synthesis and serves as a primary fuel source for cells in the intestine and immune system Glycine a simple amino acid that is vital for the synthesis of proteins, DNA, and other important molecules in the body Cysteine an amino acid that contains sulfur and is a key component of glutathione, an important antioxidant in the body Had to find a way for the cysteine molecule to not get oxidized right away Recruited a researcher from USC to help stabilize the glutathione molecule Took 2.5 years to develop a liquid, stable glutathione molecule Tried various delivery methods Oral Topical Positive charge Dr Patels first technology put a chemical cap on the cysteine molecule It did not break down immediately You could smell the sulfur People find glutathione sprays and bottles have a bit of a fart-like essence Took 13 years of modifying and testing to make a stable formula -How can you use dietary factors/dietary combinations to increase glutathione?19:53 Eat anything that has high cysteine Your body can absorb the cysteine and make glutathione out of it Cysteine-rich foods like Whey proteins Avocados Sulfur-containing products Eggs Garlic Glutamine is good for your gut You get it from supplementation, not from your diet A byproduct of the oxidation in your brain Great for someone with a leaky gut so long as it stays in the gut and the body uses it up Glutamine is implicated in Alzheimer's and Parkinson's diseases Dr

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