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doi: 10.1016/j.aohep.2019.04.013 32 AbassaK-KWuX-YXiaoX-PZhouH-XGuoY-WWuB

Betalains have also been shown to markedly supress cyclooxygenase-2 (COX-2) expression in vitro , which is an important precursor molecule for pro-inflammatory arachidonic acid metabolites known as prostaglandins [3,26,50]

However, the complex tumor microenvironment of HGSOC presents challenges for the clinical application of vaccines, with tumor-associated macrophages and other immunosuppressive cells potentially inhibiting vaccine-induced immune responses (136)

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