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More research continues to emerge on long-term outcomes and optimal patient selection criteria

The following are key considerations when counseling patients on GLP-1s: 1) Stop the medication in advance

In animal stroke models, GLP-1RAs have been associated with various beneficial direct cerebral effects, such as reduced infarct volume, apoptosis, oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity and BBB permeability, and increased neurogenesis, neuroplasticity, angiogenesis and CBF

Third, because of high circulating GLP-1 levels, glucagon secretion will be under tonic suppression in vivo