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Overall, the data support the further clinical development of cagrilintide and semaglutide 2.4 mg as a potential novel and effective combination for weight loss
It irritates the stomach lining, disrupts normal sleep, and triggers a mild inflammatory response
(2016) found that longer-term GLP-1R agonist treatments may not be useful in the weight loss process as the changes seen after short-term treatment such as improvement of activity deficits in the insula and caudate nucleus in response to palatable food did not persist during the long-term treatment (12 weeks)
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