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Week 1 (0.25mg): This is the acclimation phase. You are establishing a routine

Tirzepatide, which acts on both GLP-1 and GIP receptors, is an increasingly popular alternative

As in the prior GLP-1 trials reviewed, the GI side effects early that include vomiting, diarrhea, nausea, and constipation, occur in about half of the participants with initial dosing

The PA criteria require BMI 30 or higher (or 27 with a comorbidity such as type 2 diabetes, hypertension, dyslipidemia, OSA, or CVD), documentation of a 6-month structured weight management program, prescriber attestation that lifestyle change alone has failed, and age 18 or older