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Follistatin Gene Therapy Research in Humans Phase 1/2a clinical trial data for AAV1-FS344 in Becker muscular dystrophy patients demonstrated a statistically significant average 11.5% improvement in six-minute walk test performance at 6 months (p = 0.02), with the degree of pre-existing muscle fibrosis at baseline identified as the strongest predictor of treatment response

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GSH directly neutralizes reactive oxygen species (ROS), including hydrogen peroxide (HO) and lipid peroxides, and contributes to the detoxification of xenobiotics and electrophilic compounds through conjugation reactions mediated by glutathione S-transferases (GSTs) [36]

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