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Common Side Effects The most common adverse events reported in clinical trials include: Nausea: Reported by approximately 40% of participants, typically mild to moderate, related to melanocortin receptor activation in brainstem areas Flushing: Facial redness occurring in about 20% of users Injection site reactions: Pain, erythema, or bruising common with subcutaneous administration Headache: Affecting approximately 11% of participants These events are generally transient, occurring soon after administration and resolving within hours without intervention