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The receptor blocking approach should maximize efficacy, but also inspired concerns about the safety of the strategy

Two options are available - compounded semaglutide and compounded tirzepatide - and both require some careful reading before starting, particularly given where the FDA's regulatory posture on compounded GLP-1s stands as of mid-2026

This personalized plan also includes guidance on how to properly taper off medication when the time is right, rather than stopping abruptly, to help maintain your hard-earned results

About Mary Mary Barna Bridgeman, PharmD, BCPS, BCGP is a Clinical Professor at the Ernest Mario School of Pharmacy at Rutgers University