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Piperidine, diisopropylcarbodiimide (DIC), N -hydroxybenzotriazole (HOBt), MPAA (97%, MPAA), 3-mercaptopropionic acid (MPA), tris(2-carboxyethyl)phosphine hydrochloride (98%, TCEPHCl), thiophenol, triisopropylsilane (TIS), guanidine hydrochloride (99%, GnHCl), hydrochloric acid (reagent grade, 37%), and sodium hydroxide (pellets, 97%) as well as other reagents were purchased from Sigma Aldrich, Acros Organics or Merck and were of the purest grade available

Another study suggested that oxidative stress-induced 4-hydroxy-2-nonenal (HNE) triggers mitochondrial translocation of AIFM2, promoting apoptosis in cardiac tissues of both mice and humans 40

Another study indicates that starting treatment with a lower dose and gradually increasing it helped reduce the incidence of gastrointestinal adverse events [64]

Li C, Yuan J, Zhu YF, Yang XJ, Wang Q, Xu J, He ST, Zhang JA