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Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling

This might suggest the drug has a broader anti-ageing effect on other stem cells in the body

[5] In any research context it should still be framed research-use-only

Table I [i] BRD4 bromodomain-containing protein 4, 3-B2 2-(8-methoxy-2-methyl-4-oxoquinolin-1(4H)-yl)-N-(3-methoxyphenyl) acetamide, 10FOXM1 forkhead box M1, CoQ10 coenzyme Q10, IRF-8 interferon regulatory factor-8, PARP2 poly(ADP-ribose) polymerase 2, PVT1 plasmacytoma variant translocation 1, SCC Stachys schtschegleevii, SNHG1 small nucleolar RNA host gene 1, TIMPs tissue inhibitors of metalloproteinases