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Secher A, Lutz TA, Raun K

For patients with type 2 diabetes, alternative glucose-lowering medications such as SGLT2 inhibitors or metformin provide metabolic benefits, though with less pronounced weight effects

(87) noted in their review that co-encapsulation systems can mask astringency of different bioactive ingredients and enhance their stability and bioavailability, as well as to maximize the biological function of bioactive ingredients with synergistic effect. Importantly, they emphasized that synchronized release plays a crucial role in achieving these synergistic effects, with combined formulations showing markedly superior efficacy compared to individual components- a point that deserves particular attention (87)

Cell Death Dis, 2016