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2017;12:e0170930

Besides being more convenient for the patient, there seem to be added benefits of creating a more stable pharmacodynamics profile (i.e., reducing the peaks and troughs of drug action) as these drugs induce less nausea, a common side-effect of rapid-acting compounds (19, 50, 98, 194)

The performance of an opls model was assessed by the metrics R2Y and Q2Y which are the proportion of Y dispersion explained by the model on the training data (R2Y) and in 7-fold cross-validation (Q2Y)