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However, the problem is that most data comes from animal studies or small clinical trials, with results in humans being limited and inconclusive

Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study

doi: 10.3389/fragi.2025.1603916 Received 01 April 2025 Accepted 05 May 2025 Published 21 May 2025 Volume 6 - 2025 Edited by Augusto Schneider, Federal University of Pelotas, Brazil Reviewed by Driele Garcia, Federal University of Pelotas, Brazil Jessica Hense, Federal University of Pelotas, Brazil Updates Copyright 2025 Xie, Chen, Xu, Miao, Zheng, Jiang and Sun

In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg-40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12