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Most patients require long-term or indefinite GLP-1 therapy to maintain benefits, as discontinuation typically results in weight regain and worsening metabolic parameters
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In a second cohort that was given polyclonal IgG from vaccinated macaques or control animals, loss of TGF- and increased IL-6 production by activated pulmonary macrophages was observed in macaques that were pre-treated with anti-S IgG, and lung pathology was described as skewed towards immunopathological inflammation
Liver biopsies were performed in 66 (77.65%) patients
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