Pharmacol Ther 167:120131
spleen and liver damage Vitamin B3 (niacin): abdominal discomfort, blurred vision, high blood glucose levels, flushing, and liver damage Vitamin B6 (pyridoxine): peripheral neuropathy Vitamin B9 (folate): mental changes like irritability and confusion, seizures, skin reactions Vitamin C: diarrhea, cramps, migraines, and potentially fatal heart arrhythmiasespecially in the setting of iron overload Vitamin D: anorexia, nausea, vomiting, increased urination, increased thirst, weakness, nervousness, itching
Astrocytes are the exclusive possessors of glutamine synthetase in the brain, 137 which makes them the main target for ammonium
The causality is unclear, and confounding factors are significant, but it raises a flag that needs further investigation