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But it will be recognized by the immune system in excess, activating the Toll-like receptor 4 (TLR 4) signaling pathway, and promoting the release of immune cells to release a large number of pro-inflammatory cytokines, such as TNF- and IL-6 (Qu et al., 2023)

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The review confirmed that TB4 is released by platelets, macrophages, and many other cell types following injury, where it protects cells and tissues from further damage and reduces apoptosis, inflammation, and microbial growth