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Cardiometabolic improvements observed with semaglutide reverted towards baseline at week 120, indicating that ongoing treatment might be necessary to maintain weight loss and health improvements [1]

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Any betaine is defined as neutral zwitterionic compound possessing a positively charged cationic functional group, such as a quaternary ammonium, that has no hydrogen atoms, along with a negatively charged anionic functional group, such as a carboxylate group

Study approval The study protocol was approved by the Human Investigations Committee of the Yale School of Medicine