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CHB patients with obesity, diabetes, metabolic syndrome, or cardiovascular disease exhibit markedly higher risks of cirrhosis and HCC, reflecting accelerated inflammation and fibrosis even in the setting of antiviral HBV control (93)

Nowell J, Blunt E, Edison P (2023a) Incretin and insulin signaling as novel therapeutic targets for Alzheimers and Parkinsons disease

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Clinical studies demonstrate that semaglutide achieves glycemic control with HbA1c reductions of 1.5% to 1.8% at antidiabetic doses (Ozempic 0.5-1.0 mg, Rybelsus 7-14 mg) and produces weight loss ranging from 5-10% in type 2 diabetes and 12-15% with higher doses (Wegovy 2.4 mg) in patients with obesity