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Simultaneously, the PRMT6/USP7 complex recruits the E3 ubiquitin ligase RNF168 to sites of DNA damage, promoting H2AX monoubiquitination and robust activation of both homologous recombination (HR) and non-homologous end-joining (NHEJ) repair pathways, thereby enhancing DNA damage tolerance

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MOTS-c: Mitochondrial Longevity and Metabolic Health MOTS-c is a mitochondria-derived peptide that activates the AMPK pathway, the same cellular energy sensing pathway targeted by caloric restriction and exercise

Another early study 27 employed three SLC2A9 SNPs to identify a genetic proxy for serum UA concentration