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This combined pattern is one reason tirzepatide often produces greater average weight loss than semaglutide

They all belong to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1RAs), which mimic a hormone (GLP-1) in the body that helps control insulin and blood glucose levels and promotes feelings of satiety

BAT has important roles in both basal and adaptive energy metabolism by nonshivering thermogenesis and promotes energy expenditure to improve insulin sensitivity and reduce body weight gain 35,36,37

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