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Results: Our proposed protocol includes multilayer fat grafting (millifat, microfat, nanofat) to restore AT and support fibroblast function, scaffolds such as calcium hydroxyapatite and poly-L-lactic acid to stimulate collagen and adipogenesis, hybrid hyaluronic acid complexes for volumization, and energy-based devices including microfocused ultrasound and fractional lasers to enhance ECM remodeling and skin tightening

In severe cases, some neurological complications may become permanent if treatment starts too late.