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patients taking critical oral medications (such as thyroid hormones or anticoagulants) should discuss this with their healthcare professional Pancreatitis patients with a history of pancreatitis should exercise caution

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We agree that some patients are clinically complex and require specialized, time-intensive services in the ED, and note that this was considered during measure development

Currently there are 7 clinical trials registered for the use of itraconazole as a combinatory therapy in ovarian cancer patients and 6 in breast cancer patients (clinicaltrials.cov)