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Inflammation and Gut-Brain Axis Link Obesity to Cognitive Dysfunction: Plausible Pharmacological Interventions

doi: 10.1080/19440049.2021.1923821 132 YoshizawaT.SakamotoT.OkamotoK

Brandon Pearson evaluated biological mechanisms that could explain how prenatal acetaminophen exposure may contribute to neurodevelopmental disorders

A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)